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In people with normoglycemia and without excess adiposity, the incretin hormones GLP-1 and GIP work in concert to manage postprandial insulin levels, says Colleen Dawkins, FNP-C, RDN, CSOWM, a family nurse practitioner at Big Sky Medical Wellness, in Lakeside, Montana

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It is important to recognize that mucus in stool can result from numerous conditions unrelated to tirzepatide therapy, including irritable bowel syndrome, inflammatory bowel disease, infections, food intolerances, and other gastrointestinal disorders

But the metabolic slowdown is real, and willpower can't overcome biology