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TRT also helps reduce the amount of atherosclerotic plaquefatty, cholesterol-rich deposits that collect inside artery walls and narrow blood flowwhich could offer protection to people with cardiovascular disease
Receptor-Binding Comparison Retatrutide and Weight Loss: What the Research Shows Phase 2 Body Weight Reduction Data (Jastreboff 2023) Phase 2 data on retatrutide weight loss first appeared in the New England Journal of Medicine in 2023
In: Cochrane handbook for systematic reviews of interventions 2019
This creates an evidence gap, meaning prescribing decisions must be based on careful risk-benefit analysis rather than robust trial data in this specific population
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