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KPV is taken up into cells via the peptide transporter PepT1, particularly in intestinal epithelial and immune cells
[53] In the other three trials (NCT3987919, NCT03882970, and NCT03730662), participants were randomly assigned to receive either tirzepatide or another antidiabetic medication, and both the patient and the provider knew which medication was being given
Pyroptosis A form of programmed cell death triggered by infection or cellular stress that is, unlike apoptosis, characterized by inflammation as it involves the activation of inflammasomes and caspase-1, leading to cell swelling, membrane rupture and the release of pro-inflammatory cytokines such as interleukin-1 (IL-1) and IL-18
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