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It is capable of crossing the placenta and the blood-brain barrier, detecting concentrations in CSF of 1.5 mcg / ml after its IV infusion - Metabolism: it undergoes intense hepatic metabolism (90-95%) through conjugation reactions, mainly with glucuronic acid and sulfate

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Higher doses of any medication are more likely to cause side effects because there is more of the drug in your body, which can lead to a stronger reaction