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Clinical trials have studied continuous use up to 24 weeks with sustained benefits

Note that the paper measures an EE increase in obese animals and does not use the language of adaptive thermogenesis

When used in weight loss therapy, peptides can: Reduce hunger and cravings Slow digestion so you feel full longer Improve how your body uses insulin Boost fat metabolism Not all peptides are equal, some are FDA-approved with strong clinical evidence (like semaglutide and tirzepatide), while others are considered experimental or used off-label

Beyond the rare conditions above, a few groups should have a detailed conversation with a provider before starting