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Adverse reactions observed during Week 26 to 52 of the Phase 3 clinical trials which had an incidence of 1% and were seen more frequently with tesamorelin relative to placebo are presented in Table 2: For patients who continued from Week 26-52, mean levels of fasting blood glucose, fasting insulin, and HbA1c were not different between the T-T and T-P groups

[Note: Flavin mononucleotide, flavin adenine dinucleotide, heme, and tetrahydrobiopterin are additional coenzymes required by NOS.] 2

Following this, samples were embedded in 4% agarose gel and post-fixed in 1% osmium tetroxide