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Plus, it is important it remember, perimenopause isnt just about one hormone or one symptomits a whole-body transition

On the other hand, ECM degradation has pro-tumor effects, high ECM stiffness promotes tumor growth compared with soft ECM [166], and degradation products bind to CD44 or RHAMM, activation of Ras-MAPK, PI3K-Akt, FAK and other signaling pathways to enhance tumor cell motility [165, 167], it can also activate TGF-, and it can also activate TGF-, NF-b and other signaling to induce epithelial-mesenchymal transition (EMT) of tumor cells, to make them more invasive and migratory [168]

In fact, I am down 55lbs and A1C is down from 8.9 to 6.6