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Inside cells, the enzyme glutathione reductase (using NADPH as a cofactor) continuously regenerates GSH from GSSG, maintaining a GSH:GSSG ratio of approximately 100:1 under healthy conditions
Additionally, the combination of oxaliplatin or cyclophosphamide with anti-PD-L1 therapy has shown a synergistic effect in enhancing tumor control [169]
Treatment is typically prescribed according to the underlying cause
doi: 10.1172/jci.insight.93009 10 KongFYeSZhongZZhouXZhouWLiuZet al
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