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Safety: Its important to note that while AOD-9604 demonstrated excellent safety and tolerability, the clinical development program was ultimately discontinued because efficacy for weight loss did not meet regulatory approval standards

doi: 10.1016/j.chemosphere.2020.126690 61 KhoshgoftarmaneshA

Because of this, certain groups may want to exercise caution or avoid these supplements altogether: People taking hormone-related or other prescription medications Ingredients in hormone-support supplements may interact with treatments such as hormone replacement therapy (HRT), birth control, diabetes medications, thyroid hormones, immunosuppressants, antihypertensives, sedatives, and others.35 These interactions can alter how medications work or increase the risk of side effects

It sounds contradictory, but some patients experience overflow diarrhea. This happens when hard stool creates a blockage, and only liquid waste can leak around it