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An increased risk of NAION was noted in semaglutide users at 2 years (HR 2.39), 3 years (HR 2.44), and 4 years (HR 2.05) after treatment initiation
No randomized head-to-head trial between semaglutide 2.4 mg and tirzepatide 15 mg exists as of early 2025
It also highlighted significant weight loss benefits, which are particularly valuable for overweight or obese patients with CKD
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