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When patients get a prescription for a GLP-1, they should also be offered a referral to a Registered Dietitian to support personalized, long-term healthful behavior change, and reduce the risk of poor diet quality and nutrient deficiencies

You should always let the food be digested before doing anything strenuous as well since this can cause the same effect as laying down after eating

Damaged tissue absorbs medication differently, leading to inconsistent dosing even when your syringe measurements are perfect

The NEJM editorial accompanying the SURMOUNT-1 trial (N=2,539, tirzepatide 15 mg, 22.5% weight loss at 72 weeks) noted that access barriers to branded agents have driven patients toward unverified alternatives, and called for "pharmacy-level quality standards to be rigorously enforced before injectable peptides reach patients." [4] Patients who choose to use any compounding pharmacy should report adverse events to FDA MedWatch at fda.gov/safety/medwatch