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The side effects most people experience include nausea, vomiting, diarrhea, constipation, stomach upset, or other GI-related issues
Lower leptin levels are associated with higher risk of weight gain over 2 years in healthy young adults
Patients should: Weigh themselves once weekly at the same time and under consistent conditions Record measurements in a diary or app to identify trends Aim for gradual weight loss (NHS advises 0.51 kg per week is generally safe and sustainable) Understand that response to GLP-1 therapy varies between individuals Report unexpected rapid weight loss or gain to their healthcare provider It is important to recognise that weight loss may plateau after several months, and this does not necessarily indicate treatment failure
A 17% Reduction in Overall Cancer Risk A landmark study published in JAMA Oncology (Dai H et al., August 2025), drawing on data from 14 health systems encompassing approximately 20 million patients, found that adults with obesity who were prescribed GLP-1 receptor agonists had a 17% lower risk of developing cancer compared to carefully matched non-users
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