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Phase 3 trials have now initiated for overweight and obesity at this point, assessing CagriSema in larger numbers and for longer periods of time. References: Frias JP, et al
That doesnt make cardio the wrong choice
Dezember 2024 (zuletzt abgerufen am 13.01.2026) Ziegenhagen R et al
In addition, incretin enthusiasts had suffered a serious disappointment, when it was observed, at about the same time, that GIP although being potently insulinotropic in healthy individuals was ineffective in patients with type 2 diabetes ( not including secretin) also was a potent inhibitor of glucagon secretion ( Inspired by the similarity of GLP-1 with glucagon and oxyntomodulin, it was relevant to look at other glucagon-like gastro-intestinal actions of GLP-1, and via extensive human studies it was soon established that GLP-1 was a physiological and powerful inhibitor of gastrointestinal secretion (both gastric and pancreatic) and motility ( In spite of the disappointment with GIP in T2DM, it was time to see whether the new incretin would have any effects in T2DM patients
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