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According to the hypothesis of the monoaminergic system, depression is characterized by a reduction in levels of 5-hydroxytryptamine, dopamine (DA), and norepinephrine (NE) within the central nervous system

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A case in point, when 2 different mouse strains were exposed to therapeutic or hepatotoxic doses of APAP, depletion of GSH or APAP protein adduct formation was only detected in the liver but not in the whole brain or individual brain regions, suggesting that there is no evidence for the formation of the reactive metabolite NAPQI in the brain of adult mice [185]

[Abstract]2026 Jun 1:432:112059