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People with cardiovascular concerns should consult a healthcare professional before high-dose or long-term use
Zinc supplementation may also not be appropriate for those with HIV/AIDS, those taking antibiotics or penicillamine (Cuprimine, Depen), or those with renal (kidney) dysfunction
While transdermal patch delivery systems are under investigation, all commercially available GLP-1 therapies require subcutaneous injection (semaglutide, liraglutide, dulaglutide, tirzepatide) or oral administration (Rybelsus)
The theoretical mechanism of a GLP-1 patch would involve delivering the active pharmaceutical ingredient through the skin (transdermally) into the systemic circulation
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