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Activation of PI3K might lead to the stimulation of protein kinase B (Akt), a key regulator in the pathway, enhancing glucose transporter translocation to the cell membrane and increasing glucose uptake

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In the first reaction, L-cysteine and L-glutamate are combined by the action of the enzyme called glutamate-cysteine ligase (GSHl, 6.3.2.2), generating the intermediate y-glutamylcysteine (-EC)