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Ipamorelin, even at doses 10x above the ED50, does not produce clinically meaningful elevations in ACTH, cortisol, prolactin, or aldosterone
Before initiating GLP-1 receptor agonist therapy, clinicians should document baseline heart rate and review the patient's cardiovascular history, including any arrhythmias, heart failure, or symptoms such as palpitations
Continued vigilance is essential to support safe administration across heterogeneous cohorts
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