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If the addition of GLP-1 therapy results in heart rate elevation above target ranges, increasing the beta-blocker dose (if tolerated) may be considered
By doing this, semaglutide helps to lower blood sugar and manage weight
What weve seen in a real-world setting is those who discontinue particularly early and patients who stay on lower maintenance dosages are quite unlikely to see the weight reductions that are reported in randomized trials
The glucagon receptor activation at this dose level also increases resting heart rate by up to 6.7 beats per minute and may trigger dysesthesia (tingling or burning skin sensations) reported in 8.8% to 20.9% of participants at higher doses in Phase 3 trials
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