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10.3892/ol.2019.9971 22 ChiyomaruT.SekiN.InoguchiS.IshiharaT.MatakiH.MatsushitaR.et al
Clinical trials have demonstrated varying degrees of weight loss depending on the specific agent and dosage: semaglutide 2.4mg (Wegovy) produces approximately 15% weight loss at 68 weeks, liraglutide 3mg (Saxenda) typically achieves 5-8% weight loss, while tirzepatide has shown up to 20% weight reduction in obesity trials
A 2023 meta-analysis (Garvey et al., Obesity Reviews ) compared weight loss across GLP-1 and GLP-1/GIP trials at maximum approved doses
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