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Glucagon receptor (GCG) activation adds: Effects: Increases energy expenditure Promotes fat oxidation (burning fat for fuel) Signals satiety through brain-gut communication May enhance liver fat reduction Potentially greater effects on body composition The glucagon component matters: Research shows that glucagon signaling through the vagal nerve creates feelings of fullness, and glucagon receptor activation in the liver stimulates FGF21 secretiona hormone that helps burn fat without necessarily reducing food intake

Here, we identified a previously unrecognized role of hepatic TH action in modulating the GLP-1 and insulin secretion, which are important for the maintenance of systemic glucose homeostasis

Semaglutide is a GLP-1 drug, more formally known as a glucagon-like peptide-1 receptor agonist