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While theyre fundamentally similar medications, they differ slightly in their mechanism of action: Wegovy (semaglutide) is a GLP-1 agonist Zepbound (tirzepatide) is a dual agonist: GLP-1 + a glucose-dependent insulinotropic polypeptide (GIP) Both semaglutide and tirzepatide affect the hypothalamus and the hedonic eating centers, the brains center of appetite and cravings
The American Association of Clinical Endocrinologists and the American Diabetes Association both emphasize site rotation as a key component of injectable medication management
Lastly, the systemic effects of GLP-1RAs, such as body weight loss [103] and potential reduction in muscle mass [104], pose significant challenges for elderly individuals with neurodegenerative diseases
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