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Increasingly, their marketing is positioning blockbuster weight-loss shots not as medicines to treat obesity or diabetes but as cosmetic elixirs for anyone who wants to lose a few pounds

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Less common but important risks include dehydration from ongoing vomiting or diarrhoea, worsening diabetic eye disease in some patients with rapid glucose improvement, gallbladder problems, and pancreatitis, which is inflammation of the pancreas

In a phase 2 dose-finding trial in adults with obesity or overweight, survodutide produced dose-dependent reductions in body weight and was described as a glucagon receptorGLP-1 receptor dual agonist