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Theoretical concerns have been raised regarding cMet activation and potential tumour promotion, though shortduration studies have not observed neoplastic induction
The Wnt signaling pathway is also linked to the upregulation of ABC transporters, facilitating drug efflux and contributing to drug resistance [225]
In particular, appropriately timed light exposure is a powerful synchronizer for the SCN: morning daylight can help anchor the phase of the circadian clock, counteracting the tendency for phase advance, while minimizing bright light at night, especially blue-enriched light from screens, prevents melatonin suppression and preserves sleep quality (Voiculescu et al., 2016)
