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These mechanisms do not act independently but form an integrated regulatory network, with SIRT1 positioned centrally within the metabolismimmuneorgan axis. In processes including energy sensing, transcriptional control, redox balance, and cell fate determination, SIRT1 consistently occupies a central or upstream role in signal coordination, capable of orchestrating multiple pathways
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Tirzepatide works by targeting two important receptors in the body: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)
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