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View Study [7]"Skin Care Benefits of Copper Peptide Containing Facial Cream (as reviewed in Pickart & Margolina 2018)" Leyden J, Stephens T, Finkey MB, Appa Y, Barkovic S, 2002 Finding: A facial cream containing GHK-Cu applied for 12 weeks to 71 women with photoaging increased skin density and thickness, reduced laxity, improved clarity, and reduced fine lines and wrinkle depth

Due to the comparative small size of the rats and large size of the defects, these defects would fairly mimic large fistulas in patients that would hardly heal spontaneously

[1] [2] This triple-receptor mechanism distinguishes it from currently approved agents such as semaglutide (a GLP-1 agonist) or tirzepatide (a dual GIP/GLP-1 agonist)