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Interruptions and Discontinuation Increase Cardiovascular Risk Moreover, longer discontinuation was progressively associated with elevated MACE risk, with IRRs of 1.14 for one year of discontinuation and 1.22 for two years
Weight change during this period must be documented
Injections can still be considered in specific circumstances, such as when a neurological or haematological condition could deteriorate rapidly, or when there are serious concerns that oral treatment will not be taken reliably
Moshier, C
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