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B12 injections are water-soluble and any excess is typically excreted through urine, making overdoses rare
(However, note that when injecting intramuscularly or subcutaneously, any trace preservative is generally well tolerated
Though vitamin B12 can be consumed in the diet, many people have difficulty absorbing it and look to alternative ways to maintain healthy B12 levels
The Moderna vaccine contains a stabilized version of the ancestral spike antigen in the prefusion conformation, containing two proline mutations that prevent its switch to the fusion conformation
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