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Inflammatory cytokines can cross the blood-brain barrier, activating microglial cells (the brain's resident immune cells)
Eur J Cancer Prev (2019) 28(5):397412
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Discontinuation criteria protect patients from progressive organ damage: AST/ALT exceeding 40 IU/L Bilirubin above 21 mol/L Creatinine surpassing 90 mol/L in females These safety parameters require immediate cessation of therapy to prevent irreversible organ damage
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