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This creates a fundamentally different metabolic state

Czech Republic: Stepan Svacina, Marie Kunesova

All statistical analyses were conducted using the TwoSampleMR (for extracting genetic associations where publicly available and harmonization), MendelianRandomization and MRPRESSO (for deriving MR estimates), and meta package (for assessing heterogeneity in sex differences) in R (version 4.0.1, R Foundation for Statistical Computing, Vienna, Austria)

And the addressable population is about to expand significantly further, because the FDA approved the first oral GLP-1 formulation at the end of 2025, removing the barrier of weekly injections that has kept many potential users from starting treatment