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Spokespeople for Oz and Kennedy did not respond to requests for comment about how they would handle the policy decision
These changes lead to central sensitization, where non-painful stimuli are perceived as painful (allodynia), and pain responses are amplified (hyperalgesia)
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The Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence for the two primary biochemical outcomesserum vitamin B12 concentration increase and homocysteine reductionacross all included studies, and separately for randomised controlled trials (RCTs) and observational studies
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