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de Heer J, Rasmussen C, Coy DH, Holst JJ
Semaglutide Is the Better-Evidenced Agent Several randomized trials conducted between 2021 and 2025 showed semaglutide 1.02.4mg weekly produces roughly 1015% weight loss in PCOS patients over 612 months, with parallel improvements in menstrual cycle frequency, testosterone, sex hormone-binding globulin (SHBG), and HOMA-IR (a marker of insulin resistance)
Yao J, Zhu CQ, Sun Y, Huang YW, Li QH, Liao HM, Deng XJ, Li WM (2025) Insulin resistance: The role in comorbid type 2 diabetes mellitus and depression
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