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TAM plays a pivotal role in the progression, chemoresistance, and immune resistance in PDA (Wang et al., 2018)

This activation: Promotes directed cell migration toward injury sites Enhances cellular outgrowth from damaged tissue edges Improves cell survival during the stressful healing process Facilitates proper tissue organization This mechanism is particularly relevant for tendon and ligament healing, where cellular organization and proper fiber alignment are critical for functional recovery

However, SSRIs are not frequently used in clinical practice, and most often considered when the usage of TCAs is contraindicated

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