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Moderate caloric restriction (15-20% below maintenance) supports AOD-9604 protocols without triggering metabolic adaptation or excessive muscle loss

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Some UK product information leaflets (SmPCs) for B12 preparations do mention skin reactions as potential side effects, though not all specifically list acne

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A preclinical safety evaluation reported no minimal toxic or lethal doses in animals

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It is used to treat Vitamin B12 deficiency and associated neurological and hematological conditions

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