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These pathways are relevant in models involving appetite-related signaling, metabolic response, reward circuitry, and central nervous system regulation
[] Accordingly, we recommend that future research explore the long-term changes (e.g., 1 year) in the microbiome with the combined treatment
We typically recommend a 24 week break after 812 weeks on for chronic protocols the necessity isn't fully established, but it's a sensible conservative approach for long-term use
10.1016/j.ejphar.2006.01.037 Eur
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