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People with a history of pancreatitis Those with severe gastrointestinal disorders Individuals with h/o thyroid cancers or MEN syndrome Pregnant or breastfeeding women Seeking advice from your doctor is vital before initiating therapy

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As such, the association with efficacy may be the result of enhanced trafficking of the protein within the cell that ultimately modulates the cell surface abundance of the receptor, rather than the result of alterations in the receptor protein structure that may influence ligand affinity