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Under physiological conditions, Nrf2 remains sequestered in the cytoplasm by its inhibitor, the Kelch-like ETC-associated protein 1 (Keap1), but oxidative or electrophilic stress triggers Nrf2 dissociation, nuclear translocation, and binding to antioxidant response elements (AREs), upregulating genes such as heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutathione S-transferases (GSTs) (Simes e Silva, 2025
10.1016/B978-0-12-819815-5.00049-5 76 HardingA.SweeneyM.GovanG.Riordan-EvaP
Reconstitution refers to adding a measured volume of sterile or bacteriostatic water to the vial in order to create a solution with a known concentration, expressed as international units (IU) per millilitre (mL)
Never recap needles as this risks accidental needle stick injury
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