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The total GSH level vs storage time in months from those cohorts are shown in Figure 1, a best fit line and slope were reported for each CON, BP and SZ group

Interestingly, both Nrf2 and HO1 co-localized with reactive astrocytes, the major GSH suppliers for neighboring neurons, in the degenerating spinal cord of SOD1 G93A rats, and this was interpreted as a reactive attempt to prevent cell death

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While Rajagopalan hopes to see human data in the next year, a long road remains to a potential human treatment