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As downregulating necdin promotes adipogenic differentiation, one assumption is that those relative larger adipocytes (which need further verification) are actually well differentiated and are markers of strong expandability of AT in PWS instead
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Starting at a higher dose dramatically increases the risk and severity of gastrointestinal side effects
A long-acting once-weekly agonist does not reach its steady-state blood level after a single injection it accumulates over several doses until intake and clearance balance
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