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While current data do not show a clear association between GLP-1RA use and pulmonary aspiration, further research is needed to evaluate the risk of this potentially life-threatening complications

37 Stimulating endogenous cardiomyocyte proliferation has been proposed as a more cautious yet promising approach, as direct activation of key signaling pathways has been shown to increase cardiomyocyte proliferation, despite the low basal turnover rate in adult mammalian hearts

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Depression and anxiety are psychiatric disorders that occur in conjunction with chronic pain and contribute to the intensity of symptoms experienced by individuals with chronic pain, interfere with effective coping skills necessary to manage chronic pain, and affect treatment outcomes (20)