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In some regions, Melanotan 2 is considered a controlled substance or unauthorized in the general population for human use due to safety concerns and regulatory restrictions

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Age can also play a role, as older adults may experience more pronounced digestive side effects

Discussion In this review, we explore the roles of GLP-1R signaling in various immune cells, including macrophages, microglia, monocytes, granulocytes, CD4 + T cells, T cells, i NKT cells, NK cells and ILCs (Fig