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Sonication involves exposing samples to ultrasonic waves which agitate the molecules and increase the solubility of peptide compounds in solution
"Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection." Journal of endocrinology 150.1 (1996): 77-84
Maintenance therapy generally requires monthly injections, though some individuals benefit from biweekly administration depending on their bodys utilization rate and any ongoing absorption challenges
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