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HY: Writing review & editing, Funding acquisition, Formal analysis, Data curation

For omega-6 to omega-3 imbalance and the inflammatory-androgen axis , omega-3 supplementation has direct PCOS evidence

This can make dose escalation smoother and more tolerable

Duloxetine, a potent SNRI, reduced neuropathic pain in an animal model and significantly improved painful physical symptoms associated with depression in a study of patients with major depressive disorder [44,45]