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The high molecular homology of liraglutide to the native GLP-1(97% amino acid homology) with great protraction properties may explain the high prevalence of symptomatic cholelithiasis among liraglutide users (81.8%) than other GLP-1RAs [13, 14]
Some patients use these medications for several months to a year or more, while others may transition to maintenance dosing
Following additional FDA approvals for major adverse cardiovascular event (MACE) risk reduction in adults with established cardiovascular disease and for noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH), a tablet formulation was approved in 2025
Trulicity is also approved to lower the risk of major cardiovascular events such as heart attack or stroke in adults with type 2 diabetes and heart disease
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