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Current understanding relies heavily on extrapolation from consistent animal model results and accumulating anecdotal human reports

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For example, the topical application of a curcumin gel was found to reduce gingival bleeding and periodontal bacteria after conventional periodontal therapy (scaling and root planing) (90-92)

Lancet (London, England) 379:12561268 Stoppe C, Schlte G, Rossaint R, Coburn M, Graf B, Spillner J, Marx G, Rex S (2011) The intraoperative decrease of selenium is associated with the postoperative development of multiorgan dysfunction in cardiac surgical patients