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As fibrosis progresses, tissue stiffening and local hypoxia further promote persistent epithelial injury and myofibroblast activation, creating a vicious cycle that drives disease progression [37]
Phase 3 trial results released in December 2025 showed participants lost an average of 28.7% of their body weight (about 71 pounds) over 68 weeks, the highest weight loss reported for any obesity medication to date
Cytotoxic effects of glutathione synthesis inhibition by L-buthionine-(SR)-sulfoximine on human and murine tumor cells
Harvard Kunkalikar, Bhavana
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