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Decrease in ATP biosynthesis and dysfunction of biological membranes
The addition of GSH or expression of Grxs 1 and 2 significantly improves mutant SOD1 solubility in cell culture, whereas reducing the levels of intracellular GSH decreases SOD1 solubility, suggesting that GSH reduction promotes the aggregation of mutant SOD1 (Guareschi et al., 2012)
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Antibiotics such as levofloxacin or ciprofloxacin may reduce L-Carnitine absorption
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