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Calmes, B
In general, these enzymes catalyze a nucleophilic attack of reduced glutathione on lipophilic compounds containing an electrophilic atom (, or )
Iron overload, accumulation of reactive oxygen species (ROS) and phospholipid hydroperoxides (PLOOH), initiation of Fenton reaction and further release of PLOOH are markers of Ferroptosis (Yan et al., 2023)
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