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A third incretin-based approach is tirzepatide, a dual agonist of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR), which achieves greater HbA1c reduction and weight loss compared with GLP-1RAs alone
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Both are frozen at peak ripeness, pre-portioned, and ready in under five minutes which solves the other half of the GLP-1 breakfast problem
The SUSTAIN and STEP trial programs for semaglutide, involving thousands of participants followed for up to two years, did not demonstrate an increased overall cancer risk compared to placebo groups
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