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Hepatic PGC-1 overexpression exacerbates APAP-induced hepatotoxicity and mortality in mice Since Pgc-1 is one of the master regulators of liver metabolism and given its increased expression observed when mice were challenged with HFD, we decide to decipher whether PGC-1 induction could contribute to the worsening of APAP-induced hepatotoxicity

This chronic inflammatory state further exacerbates neuronal damage and death, creating a vicious cycle

Studies show that sustained weight reduction improves endothelial function, reduces inflammatory markers, and decreases venous stasisall factors that contribute to clot formation

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