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Healthcare providers should assess: Body composition changes (not just weight) to evaluate muscle mass preservation Glycemic control in patients with diabetes, adjusting other medications as needed Thyroid function if symptoms of hypothyroidism develop (fatigue, cold intolerance) Nutritional status through clinical assessment and laboratory testing when indicated Patients experiencing excessive fatigue, cold intolerance, or other symptoms potentially indicating metabolic suppression should be evaluated promptly, though these symptoms more commonly relate to rapid weight loss itself rather than direct drug effects

We watch for signs like less fatigue, better nerve function, and overall health

Between days 3 and 14, approximately 60-70% of users report some degree of noticeable appetite change

Levy: This is complicated because, technically, the compounding pharmacies are no longer needed to bridge the gap, so they're not supposed to make compounded tirzepatide anymore